ONECUT2

Across TCGA patient cohorts, ONECUT2 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,982 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ONECUT2-associated proteins across cancer lineages are RIF1_S782, DDX47, and CDCA8_S219. Each is linked with ONECUT2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ONECUT2-to-partner and partner-to-ONECUT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ONECUT2 versus RIF1_S782 in BRCA, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT2→partner) and Y-score (partner→ONECUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RIF1_S782 →	+0.945	+0.839	<.001	.003	3	5
LSCC	DDX47 →	+0.418	+0.623	<.001	.001	3	5
BRCA	CDCA8_S219 →	+0.780	+0.713	<.001	<.001	3	4
UCEC	CDK1 →	+0.539	+0.665	<.001	<.001	3	4
GBM	DCP2_S329 →	+1.267	+1.388	.001	.002	3	4
LSCC	UTP4 →	+0.312	+0.444	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,982 associations by consensus.

ONECUT2 vs RIF1_S782 — BRCA

Explore this scatter interactively →