ONECUT2

Across TCGA pan-cancer cohorts, ONECUT2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ONECUT2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ONECUT2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ONECUT2 is over-expressed in tumor, although a few such as THCA and CHOL show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where ONECUT2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ONECUT2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.381	<.001	11	view →
THCA	Male	III,IV	−0.124	<.001	10	view →
LUAD	Male	All	+0.648	<.001	9	view →
STAD	Male	All	+2.275	<.001	8	view →
LIHC	All	II,III,IV	+1.100	<.001	8	view →
KIRP	All	All	+0.752	<.001	8	view →
COAD	Female	All	+0.667	<.001	8	view →
READ	All	All	+0.520	.002	7	view →
LUSC	Male	II,III,IV	+0.721	<.001	6	view →
UCEC	All	All	+0.601	<.001	6	view →
BRCA	All	II,III,IV	+0.460	<.001	6	view →
CHOL	All	II,III,IV	−1.940	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ONECUT2–HNSC

Open the HNSC breakdown →