ONECUT2

Across TCGA patient cohorts, ONECUT2 protein abundance is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ONECUT2-associated genes across cancer lineages are SLC8A3, EEF1A2, and MYLK2. Each is linked with ONECUT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ONECUT2-to-partner and partner-to-ONECUT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ONECUT2 versus SLC8A3 in HNSC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT2→partner) and Y-score (partner→ONECUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC8A3 →	+0.727	+1.398	.004	.005	3	1
HNSC	EEF1A2 →	+2.678	+1.406	<.001	<.001	3	1
HNSC	MYLK2 →	+2.260	+1.638	.001	<.001	3	1
HNSC	TNNC2 →	+4.774	+2.148	<.001	<.001	3	1
HNSC	MYOM1 →	+2.820	+1.534	<.001	.002	3	1
HNSC	ST8SIA5 →	+0.297	+1.959	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

ONECUT2 vs SLC8A3 — HNSC

Explore this scatter interactively →