ONECUT2

Across TCGA patient cohorts, ONECUT2 mutation is significantly associated with the RNA expression of many other genes, with 5,866 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ONECUT2-associated genes across cancer lineages are RNU6-128P, IGHD3-16, and PRAMEF13. Each is linked with ONECUT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ONECUT2-to-partner and partner-to-ONECUT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-128P grouped by ONECUT2-low versus ONECUT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT2→partner) and Y-score (partner→ONECUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-128P →	+0.958	+4.418	<.001	.008	3	3
HNSC	IGHD3-16 →	+1.465	+3.818	<.001	.009	3	2
CESC	PRAMEF13 →	+0.050	+5.169	<.001	<.001	3	2
LUAD	RNU6-207P →	+0.601	+4.928	<.001	<.001	3	2
LUAD	RN7SL25P →	+0.425	+4.514	<.001	.002	3	2
LUAD	GAGE2E →	+0.159	+4.612	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,866 associations by consensus.

RNU6-128P by ONECUT2 expression — COAD

Explore this box plot interactively →