ONECUT2

Across TCGA patient cohorts, ONECUT2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ONECUT2-associated genes across cancer lineages are Caspase-7-cleavedD198, Shc_pY317, and TIGAR. Each is linked with ONECUT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ONECUT2-to-partner and partner-to-ONECUT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ONECUT2-low versus ONECUT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT2→partner) and Y-score (partner→ONECUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.584	+1.663	<.001	.001	3	3
UCEC	Shc_pY317 →	-0.181	-1.959	<.001	<.001	3	2
UCEC	TIGAR →	+0.108	+2.196	.009	<.001	3	2
UCEC	ATM →	-0.333	-2.986	.007	<.001	3	2
UCEC	14-3-3_beta →	-0.074	-1.636	.007	.009	3	1
UCEC	eEF2 →	+0.258	+2.415	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Caspase-7-cleavedD198 by ONECUT2 expression — UCEC

Explore this box plot interactively →