ONECUT2

Across TCGA cell cohorts, ONECUT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,834 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ONECUT2-associated GO terms across cancer lineages are DNA conformation change, Xenobiotic transmembrane transport, and Positive regulation of chemotaxis. Each is linked with ONECUT2 in more than 8 cancer types. Because this analysis shows association rather than direction, both ONECUT2-to-partner and partner-to-ONECUT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA conformation change grouped by ONECUT2-low versus ONECUT2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT2→partner) and Y-score (partner→ONECUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DNA conformation change →	+0.096	+1.360	.007	.006	2	9
LIVER	Xenobiotic transmembrane transport →	+0.163	+1.749	.001	.004	3	7
BREAST	Positive regulation of chemotaxis →	-0.095	-0.569	<.001	.005	2	8
BREAST	Antigen processing and presentation of peptide antigen →	-0.112	-0.558	<.001	.006	3	7
LUNG_SCLC	Connective tissue development →	-0.074	-2.130	<.001	<.001	3	6
CNS	Extracellular matrix assembly →	-0.113	-0.353	.003	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,834 associations by consensus.

DNA conformation change by ONECUT2 expression — LIVER

Explore this box plot interactively →