ONECUT2

Across TCGA cell cohorts, ONECUT2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ONECUT2-associated genes across cancer lineages are GUCA1C, CYP39A1, and AQP12A. Each is linked with ONECUT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ONECUT2-to-partner and partner-to-ONECUT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCA1C grouped by ONECUT2-low versus ONECUT2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ONECUT2→partner) and Y-score (partner→ONECUT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA1C →	+0.023	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CYP39A1 →	+0.209	+3.769	<.001	.008	3	1
BLOOD_Leukemia	AQP12A →	+0.091	+4.269	<.001	.002	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
BLOOD_Leukemia	MAGEL2 →	+0.379	+4.133	<.001	.003	3	1
BLOOD_Leukemia	OR6J1 →	+0.027	+4.234	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

GUCA1C by ONECUT2 expression — BLOOD_Leukemia

Explore this box plot interactively →