OLIG3

Across TCGA pan-cancer cohorts, OLIG3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated OLIG3 data layer compared with 6 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher OLIG3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OLIG3 expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

BRCA, STAD, and UCEC are the cancer types where OLIG3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	III,IV	0.785	0.927	<.001	123	view →
STAD	DFS	Tertile	II,III,IV	0.381	0.586	<.001	121	view →
UCEC	OS	Quartile	All	0.789	0.922	<.001	118	view →
SCLC	DFS	Quartile	All	0.795	0.386	<.001	57	view →
KIRC	DFS	Tertile	All	0.529	0.674	<.001	40	view →
BLCA	DFS	Tertile	III,IV	0.167	0.401	.001	39	view →
LIHC	DFS	Tertile	All	0.370	0.568	<.001	36	view →
SKCM	OS	Tertile	All	0.475	0.808	<.001	30	view →
KIRP	DFS	Quartile	All	0.594	0.754	.006	25	view →
GBM	OS	Median	All	0.268	0.501	.001	24	view →
UCS	DFS	Median	All	0.384	0.639	.008	22	view →
LGG	DFS	Tertile	All	0.720	0.840	.017	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

OLIG3–BRCA (OS)

Open the BRCA breakdown →