OLFML3

Across TCGA patient cohorts, OLFML3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLFML3-associated genes across cancer lineages are MSH6, EGFR_pY1068, and ERK2. Each is linked with OLFML3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OLFML3-to-partner and partner-to-OLFML3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by OLFML3-low versus OLFML3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFML3→partner) and Y-score (partner→OLFML3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.477	-2.321	<.001	.033	3	2
UCEC	EGFR_pY1068 →	-0.330	-2.906	.001	.001	3	1
UCEC	ERK2 →	+0.248	+3.321	.002	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-1.687	.007	.044	3	1
UCEC	Ku80 →	+0.215	+2.235	.032	.006	3	1
UCEC	MEK1 →	+0.506	+2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MSH6 by OLFML3 expression — UCEC

Explore this box plot interactively →