OLFML3

Across TCGA cell cohorts, OLFML3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OLFML3-associated genes across cancer lineages are CFC1B, TRIM60, and GPX6. Each is linked with OLFML3 in more than 1 cancer types. Because this analysis shows association rather than direction, both OLFML3-to-partner and partner-to-OLFML3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFC1B grouped by OLFML3-low versus OLFML3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFML3→partner) and Y-score (partner→OLFML3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CFC1B →	+0.006	+5.781	<.001	.001	3	1
BREAST	TRIM60 →	+0.466	+5.169	<.001	.005	3	1
BREAST	GPX6 →	+0.012	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP10-6 →	+0.068	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	LCE1C →	+0.055	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	MS4A13 →	+0.325	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

CFC1B by OLFML3 expression — BREAST

Explore this box plot interactively →