OLFML2B

Across TCGA patient cohorts, OLFML2B mutation is significantly associated with the RNA expression of many other genes, with 3,621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLFML2B-associated genes across cancer lineages are CCDC69, GINS2, and SREBF1. Each is linked with OLFML2B in more than 3 cancer types. Because this analysis shows association rather than direction, both OLFML2B-to-partner and partner-to-OLFML2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC69 grouped by OLFML2B-low versus OLFML2B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFML2B→partner) and Y-score (partner→OLFML2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CCDC69 →	-0.743	-2.889	<.001	.001	3	4
UCEC	GINS2 →	+0.755	+1.471	<.001	<.001	3	4
UCEC	SREBF1 →	+0.496	+1.280	<.001	.003	3	4
UCEC	CENPM →	+0.405	+1.885	.003	.001	3	3
UCEC	TOMM22 →	+0.252	+1.465	.008	.002	3	3
UCEC	CCDC43 →	+0.348	+1.839	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,621 associations by consensus.

CCDC69 by OLFML2B expression — LUAD

Explore this box plot interactively →