OLFML2B

Across TCGA pan-cancer cohorts, OLFML2B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of OLFML2B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OLFML2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OLFML2B is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where OLFML2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OLFML2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.860	<.001	12	view →
KIRC	Female	III,IV	+2.814	<.001	12	view →
COAD	All	IV	+1.948	<.001	11	view →
LIHC	Female	II,III,IV	+2.439	<.001	9	view →
STAD	Male	II,III,IV	+2.566	<.001	8	view →
KIRP	All	III,IV	+1.369	.009	8	view →
LUAD	All	II,III,IV	+1.126	<.001	8	view →
BRCA	All	III,IV	+1.532	<.001	6	view →
BLCA	All	All	+1.101	.006	6	view →
CHOL	All	All	+2.732	<.001	5	view →
THCA	Female	All	−0.801	<.001	4	view →
ESCA	All	All	+2.512	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

OLFML2B–HNSC

Open the HNSC breakdown →