OLFML2B

Across TCGA cell cohorts, OLFML2B mutation is significantly associated with the mutation status of many other genes, with 6,726 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OLFML2B-associated genes across cancer lineages are PLXNA2, GRM8, and ETS1. Each is linked with OLFML2B in more than 4 cancer types. Because this analysis shows association rather than direction, both OLFML2B-to-partner and partner-to-OLFML2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLXNA2 grouped by OLFML2B-low versus OLFML2B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFML2B→partner) and Y-score (partner→OLFML2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLXNA2 →	+2.893	+3.321	.003	.003	1	5
BLOOD_Leukemia	GRM8 →	+3.870	+4.050	.002	.002	1	5
BLOOD_Leukemia	ETS1 →	+5.285	+4.321	.005	.005	1	5
BLOOD_Leukemia	SLC4A10 →	+4.870	+4.560	<.001	<.001	1	5
OVARY	TBKBP1 →	+5.415	+5.415	.004	.004	1	4
OVARY	INPP5B →	+5.415	+5.415	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,726 associations by consensus.

PLXNA2 by OLFML2B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →