OLFML2A

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, OLFML2A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLFML2A-associated genes across cancer lineages are EGFR_pY1068, MEK1, and Rad50. Each is linked with OLFML2A in more than 1 cancer types. Because this analysis shows association rather than direction, both OLFML2A-to-partner and partner-to-OLFML2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFML2A→partner) and Y-score (partner→OLFML2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADEGFR_pY1068 →-0.372-3.000.006.03432
UCECMEK1 →+0.406+3.906<.001<.00132
UCECRad50 →-0.190-1.906.016.01532
UCECShc_pY317 →-0.151-1.502.002.02732
SKCMCyclin-B1 →+0.452+3.012.026.01832
SKCMJNK_pT183_Y185 →-0.153-2.321.024.03532
Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration