Across TCGA pan-cancer cohorts, OLFML2A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of OLFML2A’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OLFML2A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OLFML2A is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.
KIRC, HNSC, and LIHC are the cancer types where OLFML2A tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OLFML2A RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.