OLFM3

Across TCGA patient cohorts, OLFM3 mutation is significantly associated with the RNA expression of many other genes, with 4,530 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLFM3-associated genes across cancer lineages are PREB, CENPK, and KLF3. Each is linked with OLFM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both OLFM3-to-partner and partner-to-OLFM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREB grouped by OLFM3-low versus OLFM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFM3→partner) and Y-score (partner→OLFM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PREB →	+0.314	+4.119	.001	<.001	3	5
UCEC	CENPK →	+0.603	+2.518	<.001	.001	3	4
LUAD	KLF3 →	+0.490	+3.333	.008	.005	3	4
UCEC	SLC35G1 →	+0.406	+2.425	.001	.001	3	4
LUSC	PA2G4P4 →	+0.307	+2.333	.002	.003	3	4
LIHC	MRPL51P2 →	+0.066	+5.169	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,530 associations by consensus.

PREB by OLFM3 expression — UCEC

Explore this box plot interactively →