OLFM3

Across TCGA pan-cancer cohorts, OLFM3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OLFM3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OLFM3 RNA is repressed in tumor relative to normal tissue. In most cancer types OLFM3 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where OLFM3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OLFM3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.807	<.001	12	view →
KIRP	All	II,III,IV	−0.825	<.001	11	view →
COAD	Male	II,III,IV	−0.560	<.001	11	view →
THCA	Male	II,III,IV	−0.525	<.001	9	view →
KICH	All	All	−0.755	<.001	8	view →
STAD	All	All	−0.315	<.001	8	view →
READ	All	All	−0.821	<.001	5	view →
UCEC	All	IV	−0.500	.037	2	view →
LUSC	All	All	+0.285	.026	1	view →
LIHC	All	All	+0.087	.040	1	view →
HNSC	All	II,III,IV	−0.010	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

OLFM3–KIRC

Open the KIRC breakdown →