OLFM3

Across TCGA patient cohorts, OLFM3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLFM3-associated genes across cancer lineages are FoxM1, mTOR_pS2448, and Notch1. Each is linked with OLFM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OLFM3-to-partner and partner-to-OLFM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by OLFM3-low versus OLFM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFM3→partner) and Y-score (partner→OLFM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.180	+1.321	.037	.029	3	3
UCEC	mTOR_pS2448 →	-0.131	-3.571	.008	.002	3	2
UCEC	Notch1 →	+0.198	+2.183	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.366	+3.916	<.001	<.001	3	2
UCEC	PDCD4 →	-0.518	-3.459	<.001	.005	3	2
UCEC	Annexin-1 →	+0.431	+2.584	.014	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

FoxM1 by OLFM3 expression — UCEC

Explore this box plot interactively →