OLFM1

Across TCGA patient cohorts, OLFM1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. COAD shows the largest number of these associations.

The most reproducible OLFM1-associated genes across cancer lineages are ASNS, EGFR_pY1068, and FASN. Each is linked with OLFM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OLFM1-to-partner and partner-to-OLFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by OLFM1-low versus OLFM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFM1→partner) and Y-score (partner→OLFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.379	+1.708	.012	.026	3	3
COAD	EGFR_pY1068 →	-0.360	-2.213	.004	.010	3	2
COAD	FASN →	+0.369	+3.000	.013	.034	3	2
COAD	ATM →	-0.495	-3.000	<.001	.034	3	2
COAD	Caspase-7-cleavedD198 →	+0.821	+2.230	.006	.006	3	2
COAD	c-Kit →	-0.706	-2.213	.002	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ASNS by OLFM1 expression — COAD

Explore this box plot interactively →