OLFM1

Across TCGA pan-cancer cohorts, OLFM1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of OLFM1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OLFM1 RNA is repressed in tumor relative to normal tissue. In most cancer types OLFM1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where OLFM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OLFM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.337	<.001	11	view →
KICH	Male	All	−2.771	<.001	10	view →
COAD	Male	All	−1.326	<.001	10	view →
BLCA	Male	IV	−3.290	<.001	9	view →
LUAD	Male	All	−1.182	<.001	8	view →
KIRC	Male	II,III,IV	−1.060	<.001	7	view →
UCEC	All	All	−2.702	<.001	4	view →
BRCA	Female	II,III,IV	−0.588	<.001	4	view →
STAD	All	All	−0.768	.006	3	view →
READ	Female	All	−1.930	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

OLFM1–THCA

Open the THCA breakdown →