OLFM1

Across TCGA cell cohorts, OLFM1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible OLFM1-associated genes across cancer lineages are EDDM3A, NOBOX, and PF4V1. Each is linked with OLFM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OLFM1-to-partner and partner-to-OLFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EDDM3A grouped by OLFM1-low versus OLFM1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFM1→partner) and Y-score (partner→OLFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EDDM3A →	+0.051	+3.734	.003	.006	3	2
LUNG_NSCLC_LUSC	NOBOX →	+0.040	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PF4V1 →	+0.296	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	RXFP2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CSN2 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR13C9 →	+0.090	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

EDDM3A by OLFM1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →