OIT3

Across TCGA patient cohorts, OIT3 mutation is significantly associated with the RNA expression of many other genes, with 2,830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OIT3-associated genes across cancer lineages are C9orf50, LSM10, and TRAIP. Each is linked with OIT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OIT3-to-partner and partner-to-OIT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf50 grouped by OIT3-low versus OIT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OIT3→partner) and Y-score (partner→OIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C9orf50 →	-0.502	-3.568	.001	.002	3	3
UCEC	LSM10 →	+0.382	+2.662	<.001	<.001	3	3
SKCM	TRAIP →	+0.567	+2.404	<.001	<.001	3	3
UCEC	PGP →	+0.418	+2.169	.006	.003	3	3
UCEC	ACTBP7 →	+0.441	+2.212	.001	.001	3	3
UCEC	NF2 →	+0.427	+3.502	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,830 associations by consensus.

C9orf50 by OIT3 expression — UCEC

Explore this box plot interactively →