OGT

Across TCGA pan-cancer cohorts, OGT mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OGT data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher OGT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated OGT expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, HNSC, and GBM are the cancer types where OGT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.839	0.210	<.001	48	view →
HNSC	DFS	Median	III,IV	0.903	1.000	.004	12	view →
GBM	DFS	Median	All	0.804	0.628	.003	7	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
CCRCC	OS	Quartile	All	0.877	1.000	.013	6	view →
UCEC	DFS	Quartile	II,III,IV	0.540	0.914	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OGT–LUAD (OS)

Open the LUAD breakdown →