OGT

Across TCGA pan-cancer cohorts, OGT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OGT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where OGT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OGT is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where OGT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OGT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.418	<.001	10	view →
LIHC	All	II,III,IV	+1.110	<.001	9	view →
HNSC	All	II,III,IV	+0.415	.002	9	view →
STAD	All	II,III,IV	+0.842	.003	4	view →
BRCA	Female	All	−0.336	.001	4	view →
CHOL	All	All	+2.344	<.001	3	view →
BLCA	All	III,IV	+0.732	.008	3	view →
READ	All	All	+1.362	<.001	2	view →
PRAD	All	All	+0.608	<.001	2	view →
UCEC	All	All	−0.542	.006	2	view →
LUAD	All	All	+0.358	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

OGT–COAD

Open the COAD breakdown →