OGT

Across TCGA patient cohorts, OGT mutation is significantly associated with the RNA expression of many other genes, with 5,865 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGT-associated genes across cancer lineages are JAKMIP1, GBP5, and LSS. Each is linked with OGT in more than 2 cancer types. Because this analysis shows association rather than direction, both OGT-to-partner and partner-to-OGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JAKMIP1 grouped by OGT-low versus OGT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGT→partner) and Y-score (partner→OGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JAKMIP1 →	+0.432	+2.758	<.001	<.001	3	3
UCEC	GBP5 →	+0.951	+1.836	<.001	<.001	3	3
UCEC	LSS →	+0.442	+2.124	<.001	<.001	3	3
UCEC	ABLIM2 →	-0.356	-2.978	.003	<.001	3	3
SKCM	DCAF11 →	+0.551	+3.347	<.001	.004	3	3
HNSC	CBLL2 →	+0.044	+4.039	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,865 associations by consensus.

JAKMIP1 by OGT expression — UCEC

Explore this box plot interactively →