OGT

Across TCGA cell cohorts, OGT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,650 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OGT-associated GO terms across cancer lineages are mRNA splice site recognition, Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with OGT in more than 17 cancer types. Because this analysis shows association rather than direction, both OGT-to-partner and partner-to-OGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mRNA splice site recognition grouped by OGT-low versus OGT-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OGT→partner) and Y-score (partner→OGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.129	+1.434	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.136	+1.349	<.001	<.001	3	16
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.146	+1.232	.002	.003	3	16
BONE	Subtelomeric heterochromatin formation →	+0.121	+1.054	<.001	<.001	3	16
LUNG_SCLC	Post-transcriptional gene silencing →	+0.091	+0.791	.002	.006	3	15
OESOPHAGUS	Regulation of protein autoubiquitination →	+0.202	+1.722	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,650 associations by consensus.

mRNA splice site recognition by OGT expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →