OGT

Across TCGA cell cohorts, OGT mutation is significantly associated with the RNA expression of many other genes, with 256 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OGT-associated genes across cancer lineages are SLC32A1, GML, and FUT5. Each is linked with OGT in more than 1 cancer types. Because this analysis shows association rather than direction, both OGT-to-partner and partner-to-OGT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by OGT-low versus OGT-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGT→partner) and Y-score (partner→OGT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.789	+4.223	<.001	.001	3	1
BLOOD_Leukemia	GML →	+0.074	+3.567	<.001	.003	3	1
BLOOD_Leukemia	FUT5 →	+0.278	+3.681	<.001	.005	3	1
BLOOD_Leukemia	MMP27 →	+0.013	+3.969	<.001	.009	3	1
BLOOD_Leukemia	BRDT →	+0.143	+3.342	<.001	.006	3	1
BLOOD_Leukemia	HCN4 →	+0.037	+4.177	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 256 associations by consensus.

SLC32A1 by OGT expression — BLOOD_Leukemia

Explore this box plot interactively →