OGG1

Across TCGA patient cohorts, OGG1 mutation is significantly associated with the RNA expression of many other genes, with 2,800 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGG1-associated genes across cancer lineages are EIF2B1, PPM1G, and AUNIP. Each is linked with OGG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OGG1-to-partner and partner-to-OGG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2B1 grouped by OGG1-low versus OGG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGG1→partner) and Y-score (partner→OGG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF2B1 →	+0.396	+3.931	<.001	<.001	3	3
UCEC	PPM1G →	+0.371	+3.247	.003	<.001	3	3
UCEC	AUNIP →	+0.647	+3.467	.003	.002	3	3
UCEC	DDIAS →	+0.581	+3.467	.004	.002	3	3
UCEC	RNF34 →	+0.354	+2.330	.003	.003	3	3
UCEC	SLC25A33 →	+0.639	+2.098	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,800 associations by consensus.

EIF2B1 by OGG1 expression — UCEC

Explore this box plot interactively →