OGG1

Across TCGA pan-cancer cohorts, OGG1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OGG1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where OGG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OGG1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

COAD, LIHC, and KICH are the cancer types where OGG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OGG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.358	<.001	10	view →
LIHC	Male	All	+1.290	<.001	9	view →
KICH	Female	All	−1.496	<.001	8	view →
HNSC	Male	III,IV	+0.476	<.001	8	view →
KIRC	Male	All	−0.398	<.001	6	view →
CHOL	All	All	+0.787	<.001	3	view →
STAD	All	II,III,IV	+0.454	.003	3	view →
LUSC	All	All	−0.239	.002	3	view →
THCA	All	All	+0.195	.008	3	view →
UCEC	All	All	−0.389	.010	2	view →
BLCA	Male	IV	−0.662	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

OGG1–COAD

Open the COAD breakdown →