OGG1

Across TCGA patient cohorts, OGG1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGG1-associated genes across cancer lineages are A-Raf_pS299, PCNA, and ATM. Each is linked with OGG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OGG1-to-partner and partner-to-OGG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by OGG1-low versus OGG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGG1→partner) and Y-score (partner→OGG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.179	-3.700	<.001	.001	3	2
UCEC	PCNA →	+0.310	+3.807	<.001	<.001	2	3
UCEC	ATM →	-0.572	-2.321	.002	.006	3	2
UCEC	4E-BP1 →	+0.336	+3.351	.002	.005	3	2
UCEC	ER-alpha_pS118 →	-0.310	-1.807	.036	.027	3	1
UCEC	Gab2 →	+0.417	+2.321	.004	.006	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

A-Raf_pS299 by OGG1 expression — UCEC

Explore this box plot interactively →