OGG1

Across TCGA cell cohorts, OGG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,861 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible OGG1-associated GO terms across cancer lineages are Positive regulation of cell cycle checkpoint, Microtubule polymerization, and Depyrimidination. Each is linked with OGG1 in more than 12 cancer types. Because this analysis shows association rather than direction, both OGG1-to-partner and partner-to-OGG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle checkpoint grouped by OGG1-low versus OGG1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OGG1→partner) and Y-score (partner→OGG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of cell cycle checkpoint →	+0.130	+0.947	.001	.002	3	13
PANCREAS	Microtubule polymerization →	+0.101	+0.922	<.001	.001	3	13
BLOOD_Lymphoma	Depyrimidination →	+0.109	+1.187	<.001	<.001	3	13
SKIN	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.119	+0.872	.001	<.001	3	13
BREAST	DNA replication-dependent chromatin assembly →	+0.096	+0.918	.003	.005	3	13
SOFT_TISSUE	Microtubule nucleation →	+0.130	+1.085	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,861 associations by consensus.

Positive regulation of cell cycle checkpoint by OGG1 expression — BREAST

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