OGFRL1

Across TCGA cell cohorts, OGFRL1 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OGFRL1-associated genes across cancer lineages are ZAN, CST9, and TMEM95. Each is linked with OGFRL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OGFRL1-to-partner and partner-to-OGFRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by OGFRL1-low versus OGFRL1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGFRL1→partner) and Y-score (partner→OGFRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZAN →	+0.006	+5.369	<.001	.004	3	2
BLOOD_Lymphoma	CST9 →	+0.119	+5.209	<.001	.005	3	2
SKIN	TMEM95 →	+0.034	+4.977	<.001	.007	3	2
LUNG_NSCLC_LUAD	SLC22A8 →	+0.021	+3.628	<.001	.002	3	2
LUNG_NSCLC_LUAD	SCN10A →	+0.005	+4.662	<.001	<.001	3	2
CNS	ETDC →	+0.725	+4.754	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ZAN by OGFRL1 expression — SOFT_TISSUE

Explore this box plot interactively →