OGFR

Across TCGA patient cohorts, OGFR RNA expression is significantly associated with the go_rna of many other GO terms, with 7,158 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible OGFR-associated GO terms across cancer lineages are Regulation of type I interferon-mediated signaling pathway, tRNA thio-modification, and Response to type I interferon. Each is linked with OGFR in more than 26 cancer types. Because this analysis shows association rather than direction, both OGFR-to-partner and partner-to-OGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of type I interferon-mediated signaling pathway grouped by OGFR-low versus OGFR-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OGFR→partner) and Y-score (partner→OGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Regulation of type I interferon-mediated signaling pathway →	+0.104	+0.430	<.001	.003	3	27
UCS	tRNA thio-modification →	+0.066	+0.631	<.001	<.001	3	25
SCLC	Response to type I interferon →	+0.119	+0.553	<.001	<.001	3	25
UVM	Negative regulation of type I interferon-mediated signaling pathway →	+0.067	+0.649	<.001	<.001	2	25
SCLC	Interferon-mediated signaling pathway →	+0.107	+0.537	<.001	<.001	3	24
SCLC	Positive regulation of type I interferon-mediated signaling pathway →	+0.083	+0.578	.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,158 associations by consensus.

Regulation of type I interferon-mediated signaling pathway by OGFR expression — SCLC

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