OGFR

Across TCGA pan-cancer cohorts, OGFR RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated OGFR data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher OGFR RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OGFR expression acts as an unfavorable survival marker, although some lineages such as SKCM and COAD show a favorable association.

UVM, SKCM, and KIRC are the cancer types where OGFR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.432	0.719	.001	51	view →
SKCM	OS	Quartile	All	0.473	0.266	<.001	50	view →
KIRC	DFS	Quartile	II,III,IV	0.403	0.696	.002	48	view →
LAML	DFS	Median	All	0.257	0.472	.003	40	view →
LGG	DFS	Median	All	0.631	0.836	<.001	38	view →
KIRP	DFS	Median	IV	0.036	0.526	.004	30	view →
UCS	DFS	Tertile	IV	0.459	0.932	.024	24	view →
PRAD	DFS	Median	All	0.690	0.876	<.001	24	view →
COAD	DFS	Tertile	III,IV	0.803	0.546	.008	19	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	18	view →
LIHC	OS	Quartile	All	0.441	0.627	.008	16	view →
BLCA	DFS	Tertile	All	0.437	0.293	.017	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

OGFR–UVM (DFS)

Open the UVM breakdown →