OGFR

Across TCGA patient cohorts, OGFR mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGFR-associated genes across cancer lineages are eIF4E, p70-S6K, and Caspase-7-cleavedD198. Each is linked with OGFR in more than 1 cancer types. Because this analysis shows association rather than direction, both OGFR-to-partner and partner-to-OGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by OGFR-low versus OGFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGFR→partner) and Y-score (partner→OGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.171	+2.000	.031	.030	3	2
UCEC	p70-S6K →	+0.151	+1.792	.037	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.524	+1.765	.018	.014	3	2
UCEC	C-Raf →	+0.123	+2.169	.022	.003	3	2
UCEC	Cyclin-B1 →	+0.750	+3.906	<.001	<.001	3	2
COAD	FASN →	+0.536	+2.815	.012	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by OGFR expression — UCEC

Explore this box plot interactively →