OGFR-AS1

Across TCGA pan-cancer cohorts, OGFR-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of OGFR-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where OGFR-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types OGFR-AS1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where OGFR-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OGFR-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.887	<.001	10	view →
COAD	Male	II,III,IV	+0.487	<.001	10	view →
KIRC	Male	All	+0.290	<.001	10	view →
STAD	All	All	+0.463	<.001	4	view →
UCEC	All	All	−0.376	.004	2	view →
BLCA	All	All	+0.357	.017	2	view →
KICH	All	All	−0.290	.003	2	view →
LUSC	All	All	−0.206	.016	2	view →
HNSC	All	All	+0.133	.023	2	view →
ESCA	All	All	+0.661	.010	1	view →
READ	All	All	+0.375	.035	1	view →
LUAD	Male	II,III,IV	−0.276	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

OGFR-AS1–THCA

Open the THCA breakdown →