OGFOD3

Across TCGA pan-cancer cohorts, OGFOD3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated OGFOD3 data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher OGFOD3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated OGFOD3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and DLBC show a favorable association.

LUSC, KICH, and LIHC are the cancer types where OGFOD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	III,IV	0.607	0.891	<.001	43	view →
KICH	DFS	Median	II,III,IV	0.577	1.000	.005	31	view →
LIHC	DFS	Tertile	All	0.343	0.524	<.001	31	view →
BRCA	OS	Median	III,IV	0.940	0.865	.004	28	view →
KIRC	DFS	Quartile	IV	0.257	0.585	.015	28	view →
HNSC	OS	Tertile	All	0.600	0.802	.004	25	view →
KIRP	DFS	Median	IV	0.039	0.526	.027	24	view →
UCS	DFS	Median	II,III,IV	0.314	0.556	.020	24	view →
LGG	DFS	Quartile	All	0.774	0.903	.002	20	view →
CHOL	OS	Quartile	All	0.273	0.778	.008	14	view →
DLBC	DFS	Median	II,III,IV	0.971	0.567	.016	14	view →
ESCA	OS	Median	IV	0.222	0.698	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

OGFOD3–LUSC (OS)

Open the LUSC breakdown →