OGFOD3

Across TCGA pan-cancer cohorts, OGFOD3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of OGFOD3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where OGFOD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OGFOD3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where OGFOD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OGFOD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.588	<.001	11	view →
LIHC	Female	II,III,IV	+0.990	<.001	9	view →
COAD	Female	All	+0.554	<.001	7	view →
STAD	Male	II,III,IV	+0.714	<.001	6	view →
KIRP	All	IV	+0.822	.001	5	view →
THCA	Male	III,IV	−0.442	<.001	4	view →
CHOL	All	All	+1.257	<.001	3	view →
BLCA	All	All	+0.318	.029	3	view →
ESCA	Male	All	+0.398	.007	2	view →
KICH	All	All	−0.267	.018	2	view →
PRAD	All	All	+0.232	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

OGFOD3–HNSC

Open the HNSC breakdown →