OGFOD3

Across TCGA pan-cancer cohorts, OGFOD3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OGFOD3 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher OGFOD3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated OGFOD3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, GBM, and LUAD are the cancer types where OGFOD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.737	1.000	<.001	13	view →
GBM	OS	Median	All	0.274	0.487	.019	4	view →
LUAD	OS	Tertile	III,IV	0.845	0.319	.035	4	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.929	.036	2	view →
PDAC	OS	Median	All	0.923	0.793	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OGFOD3–CCRCC (OS)

Open the CCRCC breakdown →