OFD1

Across TCGA patient cohorts, OFD1 mutation is significantly associated with the RNA expression of many other genes, with 5,076 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OFD1-associated genes across cancer lineages are TRABD, MTA2, and ZNF598. Each is linked with OFD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OFD1-to-partner and partner-to-OFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRABD grouped by OFD1-low versus OFD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OFD1→partner) and Y-score (partner→OFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRABD →	+0.364	+3.743	.003	<.001	3	4
UCEC	MTA2 →	+0.515	+2.114	<.001	<.001	3	3
UCEC	ZNF598 →	+0.547	+1.807	<.001	<.001	3	3
UCEC	ATG4B →	+0.306	+3.054	<.001	<.001	3	3
UCEC	OTUD3 →	+0.442	+2.534	<.001	<.001	3	3
UCEC	COX8A →	+0.290	+1.606	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,076 associations by consensus.

TRABD by OFD1 expression — UCEC

Explore this box plot interactively →