OFD1

Across TCGA cell cohorts, OFD1 mutation is significantly associated with the RNA expression of many other genes, with 613 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OFD1-associated genes across cancer lineages are NDEL1, THAP9, and ACSM6. Each is linked with OFD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OFD1-to-partner and partner-to-OFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDEL1 grouped by OFD1-low versus OFD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OFD1→partner) and Y-score (partner→OFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NDEL1 →	+0.777	+3.451	<.001	.002	3	2
LARGE_INTESTINE	THAP9 →	+0.567	+3.364	.001	.002	3	2
LARGE_INTESTINE	ACSM6 →	+0.019	+2.144	<.001	.008	3	2
LARGE_INTESTINE	ZNF320 →	+1.057	+3.087	.009	.006	3	2
LARGE_INTESTINE	P2RX2 →	+0.211	+3.308	<.001	.006	3	2
LARGE_INTESTINE	WAC →	+0.659	+3.451	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 613 associations by consensus.

NDEL1 by OFD1 expression — LARGE_INTESTINE

Explore this box plot interactively →