OFCC1

Across TCGA cell cohorts, OFCC1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OFCC1-associated genes across cancer lineages are CCDC172, LBHD2, and PSKH2. Each is linked with OFCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OFCC1-to-partner and partner-to-OFCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC172 grouped by OFCC1-low versus OFCC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OFCC1→partner) and Y-score (partner→OFCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC172 →	+0.094	+5.201	<.001	.006	3	1
BLOOD_Leukemia	LBHD2 →	+0.060	+6.569	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.024	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SLC7A13 →	+0.012	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR5AR1 →	+0.053	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR8D4 →	+0.006	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CCDC172 by OFCC1 expression — BLOOD_Leukemia

Explore this box plot interactively →