ODF3

Across TCGA patient cohorts, ODF3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ODF3-associated genes across cancer lineages are A-Raf_pS299, ERK2, and Annexin-1. Each is linked with ODF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ODF3-to-partner and partner-to-ODF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ODF3-low versus ODF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ODF3→partner) and Y-score (partner→ODF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.199	-3.169	<.001	.019	3	1
UCEC	ERK2 →	+0.230	+3.169	.017	.019	3	1
UCEC	Annexin-1 →	+0.870	+3.189	<.001	.010	3	1
UCEC	S6_pS240_S244 →	+0.657	+2.321	.001	.035	3	1
UCEC	Shc_pY317 →	-0.200	-2.321	.008	.035	3	1
UCEC	STAT3_pY705 →	-0.417	-2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

A-Raf_pS299 by ODF3 expression — UCEC

Explore this box plot interactively →