ODF3

Across TCGA cell cohorts, ODF3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ODF3-associated genes across cancer lineages are TAS2R60, PRAMEF10, and PRAMEF33. Each is linked with ODF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ODF3-to-partner and partner-to-ODF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R60 grouped by ODF3-low versus ODF3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ODF3→partner) and Y-score (partner→ODF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAS2R60 →	+0.021	+4.347	.001	.001	3	1
CNS	PRAMEF10 →	+0.386	+5.754	<.001	.002	3	1
CNS	PRAMEF33 →	+0.576	+5.321	<.001	.005	3	1
LUNG_NSCLC_LUAD	GNG8 →	+0.327	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TAS2R60 by ODF3 expression — LARGE_INTESTINE

Explore this box plot interactively →