ODF1

Across TCGA patient cohorts, ODF1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ODF1-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Bad_pS112. Each is linked with ODF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ODF1-to-partner and partner-to-ODF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ODF1-low versus ODF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ODF1→partner) and Y-score (partner→ODF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.189	-3.321	.012	.010	3	1
UCEC	MEK1 →	+0.420	+2.000	.010	.032	3	1
UCEC	Bad_pS112 →	-0.168	-2.321	.046	.034	3	1
UCEC	EGFR_pY1068 →	-0.248	-2.000	.028	.032	2	1
UCEC	PCNA →	+0.332	+3.169	<.001	.019	2	1
UCEC	PDCD4 →	-0.605	-3.160	.004	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK_pT183_Y185 by ODF1 expression — UCEC

Explore this box plot interactively →