Across TCGA pan-cancer cohorts, ODF1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ODF1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ODF1 RNA is repressed in tumor relative to normal tissue. In most cancer types ODF1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.
LUSC and LUAD are the cancer types where ODF1 tumor–normal differential expression is most reproducible.