ODC1-DT

Across TCGA pan-cancer cohorts, ODC1-DT RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ODC1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ODC1-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ODC1-DT is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRP, LIHC, and KICH are the cancer types where ODC1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ODC1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.866	<.001	10	view →
LIHC	Female	II,III,IV	+0.635	<.001	9	view →
KICH	Female	II,III,IV	−1.319	<.001	7	view →
COAD	Male	All	+0.464	<.001	7	view →
UCEC	All	All	−0.490	<.001	6	view →
BRCA	All	II,III,IV	−0.457	<.001	6	view →
HNSC	All	All	+0.343	.005	6	view →
CHOL	All	All	+1.116	<.001	5	view →
LUAD	Male	All	+0.773	<.001	4	view →
BLCA	Male	IV	−1.272	<.001	2	view →
STAD	All	II,III,IV	+0.386	.018	2	view →
KIRC	All	All	+0.268	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ODC1-DT–KIRP

Open the KIRP breakdown →