ODAM

Across TCGA patient cohorts, ODAM mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ODAM-associated genes across cancer lineages are STAT3_pY705, PCNA, and Caspase-8. Each is linked with ODAM in more than 1 cancer types. Because this analysis shows association rather than direction, both ODAM-to-partner and partner-to-ODAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ODAM-low versus ODAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ODAM→partner) and Y-score (partner→ODAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.550	-3.000	<.001	.037	3	1
UCEC	PCNA →	+0.297	+3.000	.017	.037	2	1
UCEC	Caspase-8 →	-0.310	-3.000	.033	.037	2	1
UCEC	Rab25 →	-0.600	-3.000	.001	.037	1	1
UCEC	c-Met_pY1235 →	+0.112	+3.000	.008	.037	1	1
UCEC	Cyclin-B1 →	+1.040	+3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

STAT3_pY705 by ODAM expression — UCEC

Explore this box plot interactively →