ODAM

Across TCGA pan-cancer cohorts, ODAM RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ODAM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ODAM RNA is repressed in tumor relative to normal tissue. In most cancer types ODAM is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where ODAM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ODAM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.713	<.001	12	view →
THCA	Male	IV	−3.196	<.001	11	view →
LUAD	Male	III,IV	−2.875	<.001	11	view →
KIRP	Male	All	−1.453	<.001	11	view →
COAD	All	All	+1.190	<.001	7	view →
LUSC	Female	All	−2.028	<.001	6	view →
BRCA	Female	All	−0.468	<.001	6	view →
HNSC	All	II,III,IV	−1.598	.002	4	view →
LIHC	All	All	+1.145	<.001	4	view →
STAD	All	IV	−2.349	.003	2	view →
PRAD	All	All	−1.156	<.001	2	view →
UCEC	All	All	+0.845	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ODAM–KIRC

Open the KIRC breakdown →