OCSTAMP

Across TCGA patient cohorts, OCSTAMP mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OCSTAMP-associated genes across cancer lineages are Notch1, 14-3-3_beta, and FoxM1. Each is linked with OCSTAMP in more than 2 cancer types. Because this analysis shows association rather than direction, both OCSTAMP-to-partner and partner-to-OCSTAMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by OCSTAMP-low versus OCSTAMP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCSTAMP→partner) and Y-score (partner→OCSTAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.234	+2.179	<.001	.034	3	3
UCEC	14-3-3_beta →	-0.136	-2.973	.007	.035	3	1
UCEC	FoxM1 →	+0.317	+2.321	.014	.035	3	1
UCEC	Gab2 →	+0.549	+3.459	.002	.005	3	1
UCEC	JNK2 →	+0.394	+3.331	<.001	.005	3	1
UCEC	Ku80 →	+0.308	+3.179	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Notch1 by OCSTAMP expression — UCEC

Explore this box plot interactively →